Mucosal immunization of mice with recombinant OMP P2 induces antibodies that bind to surface epitopes of multiple strains of nontypeable Haemophilus influenzae.

doi:10.1038/mi.2008.70

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Article

Mucosal immunization of mice with recombinant OMP P2 induces antibodies that bind to surface epitopes of multiple strains of nontypeable Haemophilus influenzae.

Mucosal immunology - 1 Jan 2009

Ostberg K L, Russell M W, Murphy T F

Abstract excerpt

Nontypeable Haemophilus influenzae (NTHI) is a significant cause of otitis media in children and exacerbations in patients with chronic obstructive pulmonary disease. Vaccine research for NTHI has focused on the outer membrane proteins (OMPs) of NTHI. The goal of this study was to evaluate mucosal and systemic immune responses to recombinant OMP P2 (rP2) of NTHI. Enzyme-linked immunosorbent assay (ELISA)...

Topics

Animals
Antibodies, Bacterial
Antibody Formation
Antibody Specificity
Bacterial Outer Membrane Proteins
Cross Reactions
Enzyme-Linked Immunosorbent Assay
Epitopes
Haemophilus influenzae
Immunity, Mucosal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunization

Mice

Mice, Inbred BALB C

Mutation

Protein Binding

Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19079335
DOI: 10.1038/mi.2008.70
PMCID: PMC4497548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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