Characterization of a conserved outer-membrane protein in non-typeable Haemophilus influenzae with an unidentified impact on phenotype.

doi:10.1128/spectrum.02801-25

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Article

Characterization of a conserved outer-membrane protein in non-typeable Haemophilus influenzae with an unidentified impact on phenotype.

Microbiology spectrum - 7 Apr 2026

Fraser Ashley J, Cooper Oren, Forde Brian M, Murphy Timothy F, Jennings Michael P, Atack John M

Abstract excerpt

Non-typeable Haemophilus influenzae (NTHi) is an opportunistic bacterial pathogen of the human airway and is a cause of significant morbidity and mortality worldwide. No vaccine currently exists in part due to the incredible diversity and extreme variability exhibited both genetically and phenotypically between NTHi strains. For a vaccine to be successful, selection of appropriate antigens is key. Antigens need...

Topics

Haemophilus influenzae
Humans
Bacterial Outer Membrane Proteins
Phenotype
Haemophilus Infections
Antigens, Bacterial
Conserved Sequence
Lipoproteins

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Identifiers

PMID: 41837429
DOI: 10.1128/spectrum.02801-25
PMCID: PMC13055389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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