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Article

Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid Protein

26 Sept 2013

Abstract excerpt

Human rhinovirus (RV) infections are the principle cause of common colds and precipitate asthma and COPD exacerbations. There is currently no RV vaccine, largely due to the existence of ∼150 strains. We aimed to define highly conserved areas of the RV proteome and test their usefulness as candidate antigens for a broadly cross-reactive vaccine, using a mouse infection model. Regions of the VP0 (VP4+VP2) capsid...

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PMID: 24086140
DOI: 10.1371/journal.ppat.1003669

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