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Article

Nitric oxide promotes cancer cell dedifferentiation by disrupting an Oct4:caveolin-1 complex: A new regulatory mechanism for cancer stem cell formation.

The Journal of biological chemistry - 31 Aug 2018

Maiuthed Arnatchai, Bhummaphan Narumol, Luanpitpong Sudjit, Mutirangura Apiwat, Aporntewan Chatchawit, Meeprasert Arthitaya, Rungrotmongkol Thanyada, Rojanasakul Yon, Chanvorachote Pithi

Abstract excerpt

Cancer stem cells (CSCs) are unique populations of cells that can self-renew and generate different cancer cell lineages. Although CSCs are believed to be a promising target for novel therapies, the specific mechanisms by which these putative therapeutics could intervene are less clear. Nitric oxide (NO) is a biological mediator frequently up-regulated in tumors and has been linked to cancer aggressiveness. Here,...

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Identifiers

PMID: 29986880
DOI: 10.1074/jbc.RA117.000287
PMCID: PMC6120192

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