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Article

OCT4 Remodels the Phenotype and Promotes Angiogenesis of HUVECs by Changing the Gene Expression Profile.

International journal of medical sciences - 1 Jan 2016

Mou Yan, Yue Zhen, Wang Xiaotong, Li Wenxue, Zhang Haiying, Wang Yang, Li Ronggui, Sun Xin

Abstract excerpt

It has been shown that forced expression of four mouse stem cell factors (OCT4, Sox2, Klf4, and c-Myc) changed the phenotype of rat endothelial cells to vascular progenitor cells. The present study aimed to explore whether the expression of OCT4 alone might change the phenotype of human umbilical vein endothelial cells (HUVECs) to endothelial progenitor cells and, if so, to examine the possible mechanism...

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Source

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Identifiers

PMID: 27226779
DOI: 10.7150/ijms.15057
PMCID: PMC4879770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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