Article
Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer.
Breast cancer research : BCR - 12 Sept 2012
Switzer Christopher H, Cheng Robert Y-S, Ridnour Lisa A, Glynn Sharon A, Ambs Stefan, Wink David A
Abstract excerpt
INTRODUCTION: The Ets-1 transcription factor is a candidate breast cancer oncogene that regulates the expression of genes involved in tumor progression and metastasis. Ets-1 signaling has also been linked to the development of a basal-like breast cancer phenotype. We recently described a nitric oxide (NO)-induced gene signature that is associated with poor disease outcome in estrogen receptor-negative (ER-)...
Topics
- Breast Neoplasms
- Cell Line, Tumor
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- MAP Kinase Signaling System
- Matrix Metalloproteinases
- Nitric Oxide
- Nitric Oxide Synthase Type II
- Phenotype