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Article

Glutathione-S-transferase-theta genotypes and the risk of cyclophosphamide toxicity in dogs.

Veterinary and comparative oncology - 1 Dec 2018

Ekena J, Wood E, Manchester A, Chun R, Trepanier L A

Abstract excerpt

The antineoplastic agent cyclophosphamide (CP) has dose-limiting side effects including sterile haemorrhagic cystitis (SHC), bone marrow (BM) suppression and gastrointestinal (GI) toxicity in dogs. The metabolites acrolein and phosphoramide that mediate these toxicities are glutathione-S-transferase (GST) substrates, and low functioning GST alleles are associated with CP toxicity in humans. The aim of this study...

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Identifiers

PMID: 29984447
DOI: 10.1111/vco.12411

Genes

GSTT1

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