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Article

Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics.

Pharmacogenetics - 1 Dec 2002

Salavaggione Oreste E, Kidd Linda, Prondzinski Janel L, Szumlanski Carol L, Pankratz V Shane, Wang Liewei, Trepanier Lauren, Weinshilboum Richard M

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) plays an important role in the metabolism of thiopurine drugs. In humans, a common genetic polymorphism for TPMT is a major factor responsible for individual variation in the toxicity and therapeutic efficacy of these drugs. Dogs (Canis familiaris) are also t...

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Source

Identifiers

PMID: 12464800
DOI: 10.1097/00008571-200212000-00005

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12464800-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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