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Article

Influence of Genetic Variation of GST, CYP, and ABC on the Safety and Efficacy of Cyclophosphamide-Based Therapy.

Clinical and translational science - 1 Jul 2025

Yao Zhong-Wei, Li Qi-Long, Hu Wei-Feng, Pan Ling-Hui, Wu Jun-Wen, Ren Wen-Lu, Jia Hui-Tian, Wang Pan-Pan, Fu Zhi-Ying, Zhu He

Abstract excerpt

Cyclophosphamide (CTX) is one of the most widely used drugs in the clinical treatment of tumors and autoimmune diseases. The correlation between CYP, GST, and ABC gene polymorphisms and CTX activity and its induced toxicity has been extensively studied, but with inconsistent conclusions. In this study, a meta-analysis protocol was employed to comprehensively evaluate the relationship between the gene...

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Topics

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Share to ATP-Binding Cassette Transporters
Share to Cyclophosphamide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Glutathione Transferase

Share to Multidrug Resistance-Associated Protein 2

Share to Pharmacogenomic Variants

Share to Polymorphism, Single Nucleotide

Share to Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 40667789
DOI: 10.1111/cts.70301
PMCID: PMC12264835

Genes

ABCC4
CYP2C19
GSTP1
GSTT1
ABCB1
ABCG2
CYP2B6
CYP2C9
CYP3A5
GSTA1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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