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Novel mutations in avian PA in combination with an adaptive mutation in PR8 NP exacerbate the virulence of PR8-derived recombinant influenza A viruses in mice.

Veterinary microbiology - 1 Jul 2018

Lee Chung-Young, An Se-Hee, Kim Ilhwan, Choi Jun-Gu, Lee Youn-Jeong, Kim Jae-Hong, Kwon Hyuk-Joon

Abstract excerpt

The polymerase complex of the low-pathogenic avian influenza virus [A/chicken/Korea/KBNP-0028/2000] (0028) has previously been characterized, and novel amino acid residues present in the polymerase acidic protein (PA) that likely contribute to pathogenicity toward mammals have been identified. In the present study, our aims were to generate A/Puerto Rico/8/34 (PR8)-derived recombinant viruses containing the...

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PMID: 29981696
DOI: 10.1016/j.vetmic.2018.05.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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