Novel mutations in avian PA in combination with an adaptive mutation in PR8 NP exacerbate the virulence of PR8-derived recombinant influenza A viruses in mice.

Abstract excerpt

The polymerase complex of the low-pathogenic avian influenza virus [A/chicken/Korea/KBNP-0028/2000] (0028) has previously been characterized, and novel amino acid residues present in the polymerase acidic protein (PA) that likely contribute to pathogenicity toward mammals have been identified. In the present study, our aims were to generate A/Puerto Rico/8/34 (PR8)-derived recombinant viruses containing the...

Topics

• Animals
• Birds
• Cell Line
• Dogs
• Female
• Gene Expression Regulation, Viral
• Influenza A virus
• Influenza in Birds
• Mice
• Mice, Inbred BALB C
• Mutation
• Viral Proteins
• Virulence