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Article

Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice.

Journal of virology - 1 Jul 2009

Rolling Thierry, Koerner Iris, Zimmermann Petra, Holz Kristian, Haller Otto, Staeheli Peter, Kochs Georg

Abstract excerpt

High virulence of influenza virus A/Puerto Rico/8/34 in mice carrying the Mx1 resistance gene was recently shown to be determined by the viral surface proteins and the viral polymerase. Here, we demonstrated high-level polymerase activity in mammalian host cells but not avian host cells and inves...

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Identifiers

PMID: 19403683
DOI: 10.1128/JVI.00212-09
PMCID: PMC2698553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19403683-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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