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Article

Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene.

Scientific reports - 31 Aug 2017

Lee Chung-Young, An Se-Hee, Kim Ilhwan, Go Du-Min, Kim Dae-Yong, Choi Jun-Gu, Lee Youn-Jeong, Kim Jae-Hong, Kwon Hyuk-Joon

Abstract excerpt

The polymerase of avian influenza A virus (AIV) is a heterotrimer composed of PB2, PB1, and PA. PB2 plays a role in overcoming the host barrier; however, the genetic prerequisites for avian PB2 to acquire mammalian pathogenic mutations have not been well elucidated. Previously, we identified a prototypic avian PB2 that conferred non-replicative and non-pathogenic traits to a PR8-derived recombinant virus when it...

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Identifiers

PMID: 28860593
DOI: 10.1038/s41598-017-09560-z
PMCID: PMC5579056

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