Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of different NS genes of avian influenza viruses and amino acid changes on pathogenicity of recombinant A/Puerto Rico/8/34 viruses.

Veterinary microbiology - 30 Jan 2015

Kim Il-Hwan, Kwon Hyuk-Joon, Lee Su-Hyung, Kim Dae-Yong, Kim Jae-Hong

Abstract excerpt

To examine the effects of the NS1 and NEP genes of avian influenza viruses (AIVs) on pathogenicity in mice, we generated recombinant PR8 viruses containing 3 different NS genes of AIVs. In contrast to the reverse genetics-generated PR8 (rPR8) strain and other recombinant viruses, the recombinant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chickens
Share to Influenza A Virus, H9N2 Subtype
Share to Influenza in Birds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-beta

Share to Mice, Inbred BALB C

Share to Viral Load

Share to Viral Nonstructural Proteins

Source

Identifiers

PMID: 25480165
DOI: 10.1016/j.vetmic.2014.11.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25480165-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of different NS genes of avian influenza viruses and amino acid changes on pathogenicity of recombinant A/Puerto Rico/8/34 viruses.PMID 25480165Read ↗

Novel mutations in avian PA in combination with an adaptive mutation in PR8 NP exacerbate the virulence of PR8-derived recombinant influenza A viruses in mice.Semantic proximity Read ↗

Species-Specific Contribution of the Four C-Terminal Amino Acids of Influenza A Virus NS1 Protein to VirulenceSemantic proximity Read ↗

Research of Recombinant Influenza A Virus as a Vector for Mycoplasma Pneumoniae P1a and P30aSemantic proximity Read ↗

Molecular basis of efficient replication and pathogenicity of H9N2 avian influenza viruses in mice.Semantic proximity Read ↗

Amino acid mutations PB1-V719M and PA-N444D combined with PB2-627K contribute to the pathogenicity of H7N9 in mice.Semantic proximity Read ↗

Pathogenicity of different PR8 influenza A virus variants in mice is determined by both viral and host factorsSemantic proximity Read ↗

Analysis by Single-Gene Reassortment Demonstrates that the 1918 Influenza Virus Is Functionally Compatible with a Low-Pathogenicity Avian Influenza Virus in MiceSemantic proximity Read ↗

In turkeys, unlike chickens, the non-structural NS1 protein does not play a significant role in the replication and tissue tropism of the H7N1 avian influenza virusSemantic proximity Read ↗

Amino Acid Mutations A286V and T437M in the Nucleoprotein Attenuate H7N9 Viruses in MiceSemantic proximity Read ↗

Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene.Semantic proximity Read ↗

Pathogenicity of different H5N6 highly pathogenic avian influenza virus strains and host immune responses in chickensSemantic proximity Read ↗

Substitution Arg140Gly in HA/H7 Reduced the Virulence Highly Pathogenic Avian Influenza Virus H7N1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.