Article
Functional genetic variants in the SIRT5 gene promoter in acute myocardial infarction.
Gene - 30 Oct 2018
Chen Lu, Wang Haiyan, Gao Feng, Zhang Jie, Zhang Yexin, Ma Ruchao, Pang Shuchao, Cui Yinghua, Yang Jian, Yan Bo
Abstract excerpt
Coronary artery disease (CAD) including acute myocardial infarction (AMI) is a common complex disease. To date, genetic causes for atherosclerosis remain largely unknown. It has recently been proposed that low frequency and rare genetic variants may be the main causes. Mitochondrial sirtuins, SIRT3, SIRT4 and SIRT5, function as critical regulators of mitochondrial metabolism, oxidative stress and cell survival....
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