Article
Genetic analysis of the SIRT1 gene promoter in myocardial infarction.
Biochemical and biophysical research communications - 21 Sept 2012
Cui Yinghua, Wang Haihua, Chen Houzao, Pang Shuchao, Wang Lin, Liu Depei, Yan Bo
Abstract excerpt
Myocardial infarction (MI) is a restrictive phenotype of coronary artery disease. To date, a group of genes and genetic loci have been associated to MI. However, the genetic causes and underlying molecular mechanisms for MI remain largely unknown. SIRT1, one of highly conserved NAD-dependent class III deacetylases, has been involved in several cellular processes and implicated in human diseases. Autophagy is one...
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