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Article

Single Nucleotide Polymorphisms (SNPs) Distant from Xenobiotic Response Elements Can Modulate Aryl Hydrocarbon Receptor Function: SNP-Dependent CYP1A1 Induction.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2018

Liu Duan, Qin Sisi, Ray Balmiki, Kalari Krishna R, Wang Liewei, Weinshilboum Richard M

Abstract excerpt

CYP1A1 expression can be upregulated by the ligand-activated aryl hydrocarbon receptor (AHR). Based on prior observations with estrogen receptors and estrogen response elements, we tested the hypothesis that single-nucleotide polymorphisms (SNPs) mapping hundreds of base pairs (bp) from xenobiotic response elements (XREs) might influence AHR binding and subsequent gene expression. Specifically, we analyzed DNA...

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Identifiers

PMID: 29980579
DOI: 10.1124/dmd.118.082164
PMCID: PMC6090174

Genes

AHR

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Single Nucleotide Polymorphisms (SNPs) Distant from Xenobiotic Response Elements Can Modulate Aryl Hydrocarbon Receptor Function: SNP-Dependent CYP1A1 Induction.PMID 29980579Read ↗

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