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Article

Zebrafish mutants and TEAD reporters reveal essential functions for Yap and Taz in posterior cardinal vein development.

Scientific reports - 5 Jul 2018

Astone Matteo, Lai Jason Kuan Han, Dupont Sirio, Stainier Didier Y R, Argenton Francesco, Vettori Andrea

Abstract excerpt

As effectors of the Hippo signaling cascade, YAP1 and TAZ are transcriptional regulators playing important roles in development, tissue homeostasis and cancer. A number of different cues, including mechanotransduction of extracellular stimuli, adhesion molecules, oncogenic signaling and metabolism modulate YAP1/TAZ nucleo-cytoplasmic shuttling. In the nucleus, YAP1/TAZ tether with the DNA binding proteins TEADs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29976931
DOI: 10.1038/s41598-018-27657-x
PMCID: PMC6033906

Genes

YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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