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Article

Yap and Taz play a crucial role in neural crest-derived craniofacial development.

Development (Cambridge, England) - 1 Feb 2016

Wang Jun, Xiao Yang, Hsu Chih-Wei, Martinez-Traverso Idaliz M, Zhang Min, Bai Yan, Ishii Mamoru, Maxson Robert E, Olson Eric N, Dickinson Mary E, Wythe Joshua D, Martin James F

Abstract excerpt

The role of the Hippo signaling pathway in cranial neural crest (CNC) development is poorly understood. We used the Wnt1(Cre) and Wnt1(Cre2SOR) drivers to conditionally ablate both Yap and Taz in the CNC of mice. When using either Cre driver, Yap and Taz deficiency in the CNC resulted in enlarged, hemorrhaging branchial arch blood vessels and hydrocephalus. However, Wnt1(Cre2SOR) mutants had an open cranial...

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Identifiers

PMID: 26718006
DOI: 10.1242/dev.126920
PMCID: PMC4760309

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