Article

Intraflagellar transport complex B proteins regulate the Hippo effector Yap1 during cardiogenesis

2019-09-20

Abstract excerpt

Cilia and the intraflagellar transport (IFT) proteins involved in ciliogenesis are associated with congenital heart diseases (CHD). However, the molecular links between cilia, IFT proteins and cardiogenesis are yet to be established. Using a combination of biochemistry, genetics, and live imaging methods, we show that IFT complex B proteins (Ift88, Ift54 and Ift20) modulate the Hippo pathway effector YAP1 in zebra...

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Literature Corpus work: 2176bdb7-e083-58a5-9d0a-cca49a97f22f
DOI: 10.1101/777128

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