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Article

Phosphatidylinositol-3-Kinase Mutations Are Associated With Increased Local Failure in Brain Metastases Treated With Radiation.

International journal of radiation oncology, biology, physics - 15 Jul 2018

Lockney Natalie A, Wang Diana G, Pei Xin, Goldman Debra A, Zhang Zhigang, Lin Andrew, Chan Timothy A, Yamada Yoshiya, Beal Kathryn, Yang T Jonathan

Abstract excerpt

PURPOSE: To determine whether phosphatidylinositol-3-kinase (PI3K) mutations confer suboptimal local control after radiation therapy (RT) for brain metastases. METHODS AND MATERIALS: We retrospectively reviewed 259 patients with brain metastases treated with RT during the period 2004 to 2017 for whom tumor genetic data (MSK-IMPACT) were available for primary or metastatic lesions. Associations between clinical...

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PMID: 29976496
DOI: 10.1016/j.ijrobp.2018.03.032

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IMPACT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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