Article
The impact of CHEK2 status on radiosurgical outcomes in breast cancer brain metastases.
Neurosurgical review - 11 Apr 2026
Harary Paul M, Hori Yusuke S, Kattaa Ahed H, Tan Sze Kiat, Lam Fred C, Kalra Neeraj, Zagzoog Nirmeen, Tayag Armine, Ustrzynski Louisa, Emrich Sara C, Gibbs Iris C, Li Gordon, Kuno Atsushi, Park David J, Chang Steven D
Abstract excerpt
Breast cancer (BC) is a leading cause of cancer-related morbidity and mortality in women, with many patients developing brain metastases (BM). Stereotactic radiosurgery (SRS) has become a standard treatment for BCBM, achieving local control rates exceeding 90%. However, some patients remain resistant to SRS, and genetic factors may influence treatment outcomes. We aimed to evaluate the impact of CHEK2 mutations...
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