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Article

Remapping the type I diabetes association of the CTLA4 locus.

Genes and immunity - 1 Dec 2009

Qu H-Q, Bradfield J P, Grant S F A, Hakonarson H, Polychronakos C

Abstract excerpt

The Type I Diabetes Genetics Consortium genotyped 24 single-nucleotide polymorphisms (SNPs) in the CTLA4 locus in 2298 type I diabetes (T1D) nuclear families (11 159 individuals, 5003 affected) to evaluate the recognized T1D association. The 24 CTLA4 SNPs span approximately 43 kb from the 5' flanking to 3' flanking region of the gene in the middle of an extended region of linkage disequilibrium of more than 100...

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Topics

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Share to Antigens, CD
Share to CTLA-4 Antigen
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Loci

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 19956097
DOI: 10.1038/gene.2009.88
PMCID: PMC2805453

Genes

CTLA4

Variants

Provenance

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