Article
Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes.
Cell reports - 3 Jul 2018
Xu Lin, Zheng Yanbin, Liu Jing, Rakheja Dinesh, Singleterry Sydney, Laetsch Theodore W, Shern Jack F, Khan Javed, Triche Timothy J, Hawkins Douglas S, Amatruda James F, Skapek Stephen X
Abstract excerpt
Identifying oncogenic drivers and tumor suppressors remains a challenge in many forms of cancer, including rhabdomyosarcoma. Anticipating gene expression alterations resulting from DNA copy-number variants to be particularly important, we developed a computational and experimental strategy incorporating a Bayesian algorithm and CRISPR/Cas9 "mini-pool" screen that enables both genome-scale assessment of disease...
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