Article
Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer.
The Lancet. Oncology - 1 Feb 2009
Druesne-Pecollo Nathalie, Tehard Bertrand, Mallet Yann, Gerber Mariette, Norat Teresa, Hercberg Serge, Latino-Martel Paule
Abstract excerpt
Public health guidelines aim to limit the consumption of alcoholic beverages worldwide and the subsequent health burden. In particular, alcohol consumption is an avoidable risk factor for cancer. In human beings, ethanol in alcoholic drinks is mainly oxidised in the liver by alcohol dehydrogenases to acetaldehyde, and is further detoxified to acetate by aldehyde dehydrogenases. Functional variants in genes...
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