Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1.

doi:10.1161/HYPERTENSIONAHA.117.10688

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Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2018

Gray Kathryn J, Kovacheva Vesela P, Mirzakhani Hooman, Bjonnes Andrew C, Almoguera Berta, DeWan Andrew T, Triche Elizabeth W, Saftlas Audrey F, Hoh Josephine, Bodian Dale L, Klein Elisabeth, Huddleston Kathi C, Ingles Sue Ann, Lockwood Charles J, Hakonarson Hakon, McElrath Thomas F, Murray Jeffrey C, Wilson Melissa L, Norwitz Errol R, Karumanchi S Ananth, Bateman Brian T, Keating Brendan J, Saxena Richa

Abstract excerpt

The genetic susceptibility to preeclampsia, a pregnancy-specific complication with significant maternal and fetal morbidity, has been poorly characterized. To identify maternal genes associated with preeclampsia risk, we assembled 498 cases and 1864 controls of European ancestry from preeclampsia case-control collections in 5 different US sites (with additional matched population controls), genotyped samples on a...

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PMID: 29967039
DOI: 10.1161/HYPERTENSIONAHA.117.10688
PMCID: PMC6043396

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PLEKHG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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