Article
Genetic predictors of blood pressure traits are associated with preeclampsia.
Scientific reports - 30 Jul 2024
Jasper Elizabeth A, Hellwege Jacklyn N, Breeyear Joseph H, Xiao Brenda, Jarvik Gail P, Stanaway Ian B, Leppig Kathleen A, Chittoor Geetha, Hayes M Geoffrey, Dikilitas Ozan, Kullo Iftikhar J, Holm Ingrid A, Verma Shefali Setia, Edwards Todd L, Velez Edwards Digna R
Abstract excerpt
Preeclampsia, a pregnancy complication characterized by hypertension after 20 gestational weeks, is a major cause of maternal and neonatal morbidity and mortality. Mechanisms leading to preeclampsia are unclear; however, there is evidence of high heritability. We evaluated the association of polygenic scores (PGS) for blood pressure traits and preeclampsia to assess whether there is shared genetic architecture....
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