Article
Polygenic Risk Scores for Preeclampsia Prediction Beyond Gold-Standard Clinical Models in Multiethnic Populations.
Journal of the American Heart Association - 16 Dec 2025
Ardissino Maddalena, Nicolaides Kypros, Conti-Ramsden Frances, Mack Jasmine, Syngelaki Argyro, Escobar M M E, Wright Alan, Wright David, Ware James, Butterworth Adam, Williamson Catherine, Honigberg Michael, Sovio Ulla, Smith Gordon C S, Hysi Pirro, de Marvao Antonio
Abstract excerpt
BACKGROUND: Preeclampsia is a major cause of maternal and fetal mortality and morbidity. Early risk stratification enables timely preventative therapy in high-risk women. Polygenic risk scores (PGS) improve prediction in complex diseases, but their added value for preeclampsia remains unclear, particularly in comparison to gold-standard first-trimester prediction models and across non-European ancestries....
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- Adult
- Female
- Humans
- Pregnancy
- Blood Pressure