Article
Is It Time for Systematic Voriconazole Pharmacogenomic Investigation for Central Nervous System Aspergillosis?
Antimicrobial agents and chemotherapy - 1 Sept 2018
Danion François, Jullien Vincent, Rouzaud Claire, Abdel Fattah Manal, Lapusan Simona, Guéry Romain, Bigé Naïke, Morgand Marjolaine, Pallet Nicolas, Lanternier Fanny, Lortholary Olivier
Abstract excerpt
Voriconazole is the standard treatment for invasive aspergillosis but requires therapeutic drug monitoring to optimize therapy. We report two cases of central nervous system aspergillosis treated with voriconazole. Because of low trough plasma concentrations, we identified gain-of-function mutations in CYP2C19 that were partially responsible for the therapeutic failure of voriconazole. We suggest that systematic...
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