Article
Interpersonal Factors in the Pharmacokinetics and Pharmacodynamics of Voriconazole: Are CYP2C19 Genotypes Enough for Us to Make a Clinical Decision?
Current drug metabolism - 1 Jan 2018
Zhong Xuefeng, Tong Xunliang, Ju Yang, Du Xiaoman, Li Yanming
Abstract excerpt
BACKGROUND: Invasive mycoses are serious infections with high mortality and increasing incidence. Voriconazole, an important drug to treat invasive mycosis, is metabolized mainly by the cytochrome P450 family 2 subfamily C member 19 enzyme (CYP2C19) and is affected by the genotypes of CYP2C19. OBJECTIVE: We reviewed studies on how genotypes affect the pharmacokinetics and pharmacodynamics of voriconazole, and...
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