Article
Two sides of a coin: GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C.
Human immunology - 1 Sept 2018
de Lima Raul Emídio, de Holanda Martins Cyntia Maria, do Carmo Rodrigo Feliciano, Aroucha Dayse Celia Barbosa Lins, Pereira Leila Maria Moreira Beltrão, Vasconcelos Luydson Richardson Silva, Moura Patrícia
Abstract excerpt
The complement system (CS) is a key element of immunity against pathogens but also seems to influence other events, such as tumorigenesis and tissue repair. Complement component 7 (C7) is a key component of the lytic pathway of CS, leading to the formation of the membrane attack complex (MAC). This study aimed to investigate the existence of the association of a polymorphism in the C7 gene, rs1063499, with...
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