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Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets

1 Jan 2023

Abstract excerpt

BACKGROUND/AIMS: To evaluate the causal correlation between complement components and non-viral liver diseases and their potential use as druggable targets. METHODS: We conducted Mendelian randomization (MR) to assess the causal role of circulating complements in the risk of non-viral liver diseases. A complement-centric protein interaction network was constructed to explore biological functions and identify...

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PMID: 38061333
DOI: 10.3350/cmh.2023.0343

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