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The essential calcium channel of sperm CatSper is temperature-gated

17 Apr 2025

Abstract excerpt

Abstract The flagellar calcium channel CatSper is essential for male fertility, as it regulates calcium influx to trigger the hyperactive motility required for sperm to fertilize the egg. Precise activation of CatSper is critical, as premature activation can impair sperm function. While optimal temperature is known to influence fertilization, its effect on CatSper remains unknown. By directly recording from mouse...

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PMID: 40246904
DOI: 10.1038/s41467-025-58824-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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