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Article

Widespread Allelic Heterogeneity in Complex Traits.

American journal of human genetics - 4 May 2017

Hormozdiari Farhad, Zhu Anthony, Kichaev Gleb, Ju Chelsea J-T, Segrè Ayellet V, Joo Jong Wha J, Won Hyejung, Sankararaman Sriram, Pasaniuc Bogdan, Shifman Sagiv, Eskin Eleazar

Abstract excerpt

Recent successes in genome-wide association studies (GWASs) make it possible to address important questions about the genetic architecture of complex traits, such as allele frequency and effect size. One lesser-known aspect of complex traits is the extent of allelic heterogeneity (AH) arising from multiple causal variants at a locus. We developed a computational method to infer the probability of AH and applied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28475861
DOI: 10.1016/j.ajhg.2017.04.005
PMCID: PMC5420356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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