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Article

Reappraisal of Reported Genes for Sudden Arrhythmic Death: Evidence-Based Evaluation of Gene Validity for Brugada Syndrome.

Circulation - 18 Sept 2018

Hosseini S Mohsen, Kim Raymond, Udupa Sharmila, Costain Gregory, Jobling Rebekah, Liston Eriskay, Jamal Seema M, Szybowska Marta, Morel Chantal F, Bowdin Sarah, Garcia John, Care Melanie, Sturm Amy C, Novelli Valeria, Ackerman Michael J, Ware James S, Hershberger Ray E, Wilde Arthur A M, Gollob Michael H

Abstract excerpt

BACKGROUND: Implicit in the genetic evaluation of patients with suspected genetic diseases is the assumption that the genes evaluated are causative for the disease based on robust scientific and statistical evidence. However, in the past 20 years, considerable variability has existed in the study design and quality of evidence supporting reported gene-disease associations, raising concerns of the validity of many...

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Source

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Identifiers

PMID: 29959160
DOI: 10.1161/CIRCULATIONAHA.118.035070
PMCID: PMC6147087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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