Article
Threshold-stimulated kallikrein activity distinguishes bradykinin- from histamine-mediated angioedema.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2018
Lara-Marquez Maria L, Christiansen Sandra C, Riedl Marc A, Herschbach Jack, Zuraw Bruce L
Abstract excerpt
BACKGROUND: The lack of specific biomarkers makes the diagnosis of hereditary angioedema (HAE) with normal levels of C1-inhibitor (C1INH) protein (HAE-nl-C1INH) and idiopathic non-histaminergic angioedema (INHA) difficult. Confirming or excluding these diagnoses is a significant challenge for clinicians evaluating patients with angioedema. OBJECTIVE: To develop a reliable biomarker that would aid the diagnosis of...
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