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Human Aging and Longevity Are Characterized by High Levels of Mitokines

27 Jun 2018

Abstract excerpt

Mitochondrial stress elicits the production of stress response molecules indicated as mitokines, including fibroblast growth factor 21 (FGF21), growth differentiation factor 15 (GDF15), and humanin (HN). Many diseases are characterized by progressive mitochondrial dysfunction with alterations of mitokine secretion. It is still controversial whether healthy aging and extreme longevity are accompanied by an altered...

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PMID: 29955888
DOI: 10.1093/gerona/gly153

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