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Article

Serum fibroblast growth factor 21 and growth differentiation factor 15: Two sensitive biomarkers in the diagnosis of mitochondrial disorders.

Mitochondrion - 1 Sept 2021

Huddar Akshata, Govindaraj Periyasamy, Chiplunkar Shwetha, Deepha Sekar, Jessiena Ponmalar J N, Philip Mariyamma, Nagappa Madhu, Narayanappa Gayathri, Mahadevan Anita, Sinha Sanjib, Taly Arun B, Parayil Sankaran Bindu

Abstract excerpt

Mitochondrial disorders are often difficult to diagnose because of diverse clinical phenotypes. FGF-21 and GDF-15 are metabolic hormones and promising biomarkers for the diagnosis of these disorders. This study has systematically evaluated serum FGF-21 and GDF-15 levels by ELISA in a well-defined cohort of patients with definite mitochondrial disorders (n = 30), neuromuscular disease controls (n = 36) and healthy...

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PMID: 34419687
DOI: 10.1016/j.mito.2021.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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