Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers.

Nature communications - 3 Oct 2016

Kim Jin-Ah, Tan Ying, Wang Xian, Cao Xixi, Veeraraghavan Jamunarani, Liang Yulong, Edwards Dean P, Huang Shixia, Pan Xuewen, Li Kaiyi, Schiff Rachel, Wang Xiao-Song

Abstract excerpt

More aggressive and therapy-resistant oestrogen receptor (ER)-positive breast cancers remain a great clinical challenge. Here our integrative genomic analysis identifies tousled-like kinase 2 (TLK2) as a candidate kinase target frequently amplified in ∼10.5% of ER-positive breast tumours. The resulting overexpression of TLK2 is more significant in aggressive and advanced tumours, and correlates with worse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Design
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Gene Silencing

Share to MCF-7 Cells

Share to Neoplasm Transplantation

Share to Protein Kinases

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 27694828
DOI: 10.1038/ncomms12991
PMCID: PMC5064015

Genes

TLK2
BCL2
EGFR
SKP2
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers.PMID 27694828Read ↗

Molecular basis of Tousled-Like Kinase 2 activation.Semantic proximity Read ↗

TLK2 enhances aggressive phenotypes of glioblastoma cells through the activation of SRC signaling pathwaySemantic proximity Read ↗

Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challengesSemantic proximity Read ↗

CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast CancerSemantic proximity Read ↗

Comprehensive Pan-Cancer Analysis of 33 Human Cancers Reveals Immunotherapeutic Value of FAK/PTK2Semantic proximity Read ↗

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapySemantic proximity Read ↗

Tinengotinib (TT-00420), a Novel Spectrum-Selective Small-Molecule Kinase Inhibitor, Is Highly Active Against Triple-Negative Breast CancerSemantic proximity Read ↗

The serine-threonine kinase TAO3 promotes cancer invasion and tumor growth by facilitating trafficking of endosomes containing the invadopodia scaffold TKS5αSemantic proximity Read ↗

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapySemantic proximity Read ↗

Evaluating the Therapeutic Viability of Bacterially Expressed Human TLK1B-Kinase Domain for Cancer Drug DesignSemantic proximity Read ↗

MAP kinase ERK5 modulates cancer cell sensitivity to extrinsic apoptosis induced by death-receptor agonists and Natural Killer cellsSemantic proximity Read ↗

Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.