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Article

Pharmacogenetic evaluation of a DISP1 gene variant in antidepressant treatment of obsessive-compulsive disorder.

Human psychopharmacology - 1 Jul 2018

Lisoway Amanda J, Zai Gwyneth, Tiwari Arun K, Zai Clement C, Wigg Karen, Goncalves Vanessa, Zhang Danning, Freeman Natalie, Müller Daniel J, Kennedy James L, Richter Margaret A

Abstract excerpt

OBJECTIVES: A recent genome-wide association study (GWAS) in obsessive-compulsive disorder (OCD) reported a significant marker in the dispatched homolog 1 (Drosophila) gene (DISP1 gene) associated with serotonin reuptake inhibitor (SRI) antidepressant response (Qin et al., ). DISP1 has never been examined before in terms of association with SRI response until this GWAS. We attempt to replicate the GWAS finding by...

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Identifiers

PMID: 29953682
DOI: 10.1002/hup.2659

Genes

SRI
DISP1

Provenance

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