Article
Haplotypes of ABCB1 1236C >T (rs1128503), 2677G >T/A (rs2032582), and 3435C >T (rs1045642) in patients with bullous pemphigoid.
Archives of dermatological research - 1 Aug 2018
Rychlik-Sych Mariola, Barańska Małgorzata, Dudarewicz Michał, Skrętkowicz Jadwiga, Żebrowska Agnieszka, Woźniacka Anna, Owczarek Jacek, Orszulak-Michalak Daria, Waszczykowska Elżbieta
Abstract excerpt
Bullous pemphigoid (BP) constitutes the most prevalent disease in the group of bullous dermatoses with the autoimmune background. Some authors suggest that certain cytokines (IL-2, IFN-γ) may be transported by P-glycoprotein (P-gp), the product of the ABCB1 gene. ABCB1 polymorphism might affect not only the effectiveness of treatment with drugs that are P-gp substrates but also contribute to the development of...
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