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Article

Efficient analysis of mouse genome sequences reveal many nonsense variants.

Proceedings of the National Academy of Sciences of the United States of America - 17 May 2016

Steeland Sophie, Timmermans Steven, Van Ryckeghem Sara, Hulpiau Paco, Saeys Yvan, Van Montagu Marc, Vandenbroucke Roosmarijn E, Libert Claude

Abstract excerpt

Genetic polymorphisms in coding genes play an important role when using mouse inbred strains as research models. They have been shown to influence research results, explain phenotypical differences between inbred strains, and increase the amount of interesting gene variants present in the many available inbred lines. SPRET/Ei is an inbred strain derived from Mus spretus that has ∼1% sequence difference with the...

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Identifiers

PMID: 27147605
DOI: 10.1073/pnas.1605076113
PMCID: PMC4878497

Genes

IRAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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