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Article

A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models

23 Dec 2018

Abstract excerpt

Haematopoietic stem cell (HSC) transplantation is a critical therapy for haematopoietic malignancies and immune disorders. Incomplete or delayed engraftment of HSCs in the host results in increased risk of infection and morbidity. The mechanisms of HSC engraftment are poorly understood and understanding these processes will increase transplantation success on many levels. Current animal models are...

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PMID: 29946444
DOI: 10.12688/f1000research.14507.2

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