Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accumulation of Malignant Renal Stem Cells Is Associated with Epigenetic Changes in Normal Renal Progenitor Genes

8 May 2008

Abstract excerpt

Recent studies indicate a dual epigenetic role of the Polycomb group (PcG) proteins in self-renewal of stem cells and oncogenesis. Their elevation in our previous human kidney microarray screen led us examine whether they participate in processes involving normal and malignant renal progenitors. We therefore analyzed the expression of the PcG genes (EZH2, BMI-1, EED, SUZ12) in relation to that of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Renal and related cancers
Share to Renal cell carcinoma treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18467665
DOI: 10.1634/stemcells.2007-0322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accumulation of Malignant Renal Stem Cells Is Associated with Epigenetic Changes in Normal Renal Progenitor GenesPMID 18467665Read ↗

Multiple Imprinted and Stemness Genes Provide a Link between Normal and Tumor Progenitor Cells of the Developing Human KidneySemantic proximity Read ↗

Emerging Transcriptional Mechanisms in the Regulation of Epithelial to Mesenchymal Transition and Cellular Plasticity in the KidneySemantic proximity Read ↗

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.Semantic proximity Read ↗

EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells.Semantic proximity Read ↗

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cellsSemantic proximity Read ↗

Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.Semantic proximity Read ↗

Polycomb complexes in normal and malignant hematopoiesisSemantic proximity Read ↗

Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.Semantic proximity Read ↗

Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1Semantic proximity Read ↗

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and CancerSemantic proximity Read ↗

Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity.Semantic proximity Read ↗

Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.