Article
DeTiN: overcoming tumor-in-normal contamination.
Nature methods - 1 Jul 2018
Taylor-Weiner Amaro, Stewart Chip, Giordano Thomas, Miller Mendy, Rosenberg Mara, Macbeth Alyssa, Lennon Niall, Rheinbay Esther, Landau Dan-Avi, Wu Catherine J, Getz Gad
Abstract excerpt
Comparison of sequencing data from a tumor sample with data from a matched germline control is a key step for accurate detection of somatic mutations. Detection sensitivity for somatic variants is greatly reduced when the matched normal sample is contaminated with tumor cells. To overcome this limitation, we developed deTiN, a method that estimates the tumor-in-normal (TiN) contamination level and, in cases...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.