Article

Generation of nonhuman primate retinitis pigmentosa model by <i>in situ</i> knockout of <i>RHO</i> in rhesus macaque retina

2020-07-31

Abstract excerpt

Retinitis pigmentosa (RP) is a form of inherited retinal degenerative disease that ultimately involves the macula, which is present in primates but not in the rodents. Therefore, creating nonhuman primate (NHP) models of RP is of critical importance to study its mechanism of pathogenesis and to evaluate potential therapeutic options in the future. Here we applied adeno-associated virus (AAV)-delivered CRISPR/SaCas...

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Literature Corpus work: e90e508c-9eda-5af6-8687-6b83ca2fc45c
DOI: 10.1101/2020.07.29.226787

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