EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association.

doi:10.1093/nar/gky536

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Article

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association.

Nucleic acids research - 6 Sept 2018

Paredes Roberto, Schneider Marion, Stevens Adam, White Daniel J, Williamson Andrew J K, Muter Joanne, Pearson Stella, Kelly James R, Connors Kathleen, Wiseman Daniel H, Chadwick John A, Löffler Harald, Teng Hsiang Ying, Lovell Simon, Unwin Richard, van de Vrugt Henri J, Smith Helen, Kustikova Olga, Schambach Axel, Somervaille Tim C P, Pierce Andrew, Whetton Anthony D, Meyer Stefan

Abstract excerpt

The transcriptional regulator EVI1 has an essential role in early hematopoiesis and development. However, aberrantly high expression of EVI1 has potent oncogenic properties and confers poor prognosis and chemo-resistance in leukemia and solid tumors. To investigate to what extent EVI1 function might be regulated by post-translational modifications we carried out mass spectrometry- and antibody-based analyses and...

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PMID: 29939287
DOI: 10.1093/nar/gky536
PMCID: PMC6125627

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