Article
Integration of the SV40 promoter/enhancer sequences in an anchorage-independent clonal subline of SV40-infected human keratinocytes.
Gene - 12 Dec 1996
Chen G, Baez J M, Steinberg M L
Abstract excerpt
Long-term cultures of SV40-infected human keratinocytes contain integrated, but structurally altered copies of the viral sequences. The presence of these sequences is required for expression of properties associated with the transformed phenotype including immortalization. The integrated viral se...
Topics
- Antigens, Polyomavirus Transforming
- Cell Adhesion
- Cell Line, Transformed
- DNA, Viral
- Enhancer Elements, Genetic
- Genetic Variation
- Humans
- Keratinocytes
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- RNA, Messenger
- Simian virus 40
- Virus Integration