Article
Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli.
PLoS genetics - 3 Oct 2008
Gonzalez Caleb, Hadany Lilach, Ponder Rebecca G, Price Mellanie, Hastings P J, Rosenberg Susan M
Abstract excerpt
In bacterial, yeast, and human cells, stress-induced mutation mechanisms are induced in growth-limiting environments and produce non-adaptive and adaptive mutations. These mechanisms may accelerate evolution specifically when cells are maladapted to their environments, i.e., when they are are stressed. One mechanism of stress-induced mutagenesis in Escherichia coli occurs by error-prone DNA double-strand break...
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