Article
Continuous-Trait Probabilistic Model for Comparing Multi-species Functional Genomic Data.
Cell systems - 22 Aug 2018
Yang Yang, Gu Quanquan, Zhang Yang, Sasaki Takayo, Crivello Julianna, O'Neill Rachel J, Gilbert David M, Ma Jian
Abstract excerpt
A large amount of multi-species functional genomic data from high-throughput assays are becoming available to help understand the molecular mechanisms for phenotypic diversity across species. However, continuous-trait probabilistic models, which are key to such comparative analysis, remain under-explored. Here we develop a new model, called phylogenetic hidden Markov Gaussian processes (Phylo-HMGP), to...
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