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Article

The architecture of an empirical genotype-phenotype map.

Evolution; international journal of organic evolution - 1 Jun 2018

Aguilar-Rodríguez José, Peel Leto, Stella Massimo, Wagner Andreas, Payne Joshua L

Abstract excerpt

Recent advances in high-throughput technologies are bringing the study of empirical genotype-phenotype (GP) maps to the fore. Here, we use data from protein-binding microarrays to study an empirical GP map of transcription factor (TF) -binding preferences. In this map, each genotype is a DNA sequence. The phenotype of this DNA sequence is its ability to bind one or more TFs. We study this GP map using genotype...

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PMID: 29676774
DOI: 10.1111/evo.13487
PMCID: PMC6055911

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